2021 Volume 74 Issue 4 Pages 155-169
It has been pointed out that excessive intake of fructose is associated with the development of metabolic syndrome. The physiological effects of fats and oils differ greatly depending on the fatty acids they contain. This study compared the effects of different fats and oils in a high fructose diet in rats. When the rats were fed a high fructose diet containing fish oil (FO), soybean oil (SO) or medium-chain triglycerides (MCT) using lard (LD) as a control for 4 weeks, the FO group exhibited a remarkable improvement in lipid metabolism. Although the SO group exhibited a decrease in hepatic lipids, the effect was smaller than that in the FO group. In the MCT group, the expression of genes related to fatty acid synthesis in mesenteric fat was remarkably high, and no improvement of lipid metabolism was observed. The hepatic protein expression profile in the FO group differed from that in the other groups. Increased protein expression associated with fatty acid oxidation and the oxidative stress response was observed in the FO group. These results revealed a difference in the physiological effects of fats and oils in a high fructose diet.
