Abstract
The effect of thiamine on urease was studied, and the results obtained were as follows:-
1.The activity of urease previously inactivated by AgNO3, was not recovered by thiamine of 5×10-3M concentration or of below this.
2.About 1994 inhibition of the activity of urease was caused by the addition of thiamine at the concentration of 10-3M and 2×10-3M, but no inhibition took place at the concentration of 1/3×10-3M or at lower concentrations.
3.The activity of urease was not inhibited by pyrimidine derivatives and thiazole, or by the mixture of them, whereas it was inhibited by thiochrome at concentrations equivalent to those of 10-3M thiamine.
These results seem to suggest that the combination of pyrimidine and thiazole is essential for inhibition of urease activity by thiamine.
