Abstract
A study was made of poliovirus antibody production by cows and administration of the immune milk on monkeys. The change in the antibody level of serum and milk of pregnant or multiparous cows after intramuscular injection of anti-poliovirus vaccine, the change of the antibody activity after thermal treatment, and the change in the serum antibody level of monkeys after oral administration of the immune dried milk were examined.
1) The immunization with anti-poliovirus vaccine on pregnant cow increased the neutralizing antibody level of its serum and milk to >4, 096x as compared to 4 to 64x of the serum and 4 to 32x of the milk before the immunization.
2) The neutralizing antibody level of milk decreased rapidly; the level returned to the initial one in two weeks after the delivery.
3) The administration of immune colostrum on a calf increased the neutralizing antibody level of its serum to 512x, as compared to 4x before the administration.
4) Heating for 30 minutes at 63°C caused no decrease in the neutralizing antibOdy level of milk.
5) One of four monkeys fed the immune dried milk for 15 days gave a serum antibody level of 8x.
