Abstract
Animal experiments were conducted to determine whether administration of dehydroascorbic acid to guinea pig produces diabetes as in the case of rat or prevents diabetes and elevates succinic dehydrogenase which has been in low level by deficiency of ascorbic acid. In one experiment effect of deficiency of ascorbic acid on pyruvic dehydrogenase in liver was also studied.
1) Whereas succinic dehydrogenase activity was decreased significantly in deficiency of ascorbic acid, pyruvic dehydrogenase activity did not.
2) After administration of dehydroascorbic acid to deficient animals ascorbic acid concentration in both plasma and liver and level of succinic dehydrogenase in liver recovered to normal.
