Abstract
6-Azauracil, β-alanine or carnosine was subcutaneously injected to male Wistar strain rats for a 15 days period (10mg/day/rat). The gain of body weight and the orotate excretion were measured daily. The contents of β-alanine, anserine and carnosine in several organ preparations were determined by an amino acid autoanalyzer on the 16th day. At the same time RNA and DNA of these preparations were also estimated using conventional technique.
The contents of β-alanine, anserine and carnosine were markedly increased by the 6-azauracil or β-alanine treatment. After carnosine treatment, anserine was found in the liver and small intestine. High concentration (2.7 hold of normal case) of anserine was found in the gastrocnemius. β-Alanine was also increased in some organs and found in the spleen and gastrocnemius. By the carnosine or β-alanine treatment the content of RNA was increased in the several organs, but not DNA.
