Abstract
Anorexigenic activity of FMS-1A extracted from rat urine by the method of Stevenson et al. was examined. The significant reduction in body weight and anorexigenic effect on food and water intake were followed by the intraperitoneal injection of FMS-1A into rats. It was demonstrated that FMS-1A was a substance related to protein, and its anorexigenic activity remained after standing at room temperature for 10 days. Then the collected rat urine was concentrated by ultrafiltration method and fractionated. A fraction having molecular weight more than 5, 000 also showed the anorexigenic activity. This result suggests that anorexigenic substance is present in normal rat urine, but it gets no activity by treatment of alcohol and/or benzoic acid.
