Abstract
In the present paper, the authors studied changes of the serum composition and histologic features in hypersensitiveness to light of the rats fed on salted takana.
Three groups of rats were fed on casein diet containing 0.5g, 1.0g or 1.5g of salted takana per head, and then these groups were exposed to 20, 000 luxes visible light. All of these rats became restless and then showed edema on the neck and the back of body, and finally died within several hours. Mean survival period of each animals were calculated to be 189, 75 or 38 minutes respectively.
These hypersensitiveness were relatively soon released when they ceased to take salted takana. None of these treated rats died at the exposure of light after refeeding on normal casein diet only for two days. Therefore it may be possible that the photodynamic substance in salted takana is not so long time remained in animal body.
In the serum analysis of irradiated rats, albumin fraction was found to be decreased, but potassium concentration and TBA value were shown to be increased significantly, and GOT, GPT and LDH activities were elevated.
In the histopathological examination, exsudative dermatitis, myositis and congestion of organs were observed. Sudden death of these treated rats may be attributed to failure of peripheral circulation.
