The Effect of Protease Inhibitor on Tyrosine and N^τ-Methylhistidine Release from Incubated Diaphragm

Abstract

The protease inhibitor leupeptin decreased tyrosine release from rat diaphragm incubated in vitro while pepstatin did not decrease tyrosine release. Leupeptin also decreased N^τ-methylhistidine release. These results suggested that protease being inhibited by leupeptin degraded muscle proteins and myofibrillar proteins.