1987 Volume 40 Issue 6 Pages 485-495
The effects of administration of a diet containing medium-chain triglyceride (MCT) on lipid metabolism in gastrectomized rats were studied, together with the effects on liver function and serum ketone bodies. The results obtained were as follows.
1) The concentrations of cholesterol (CHO), phospholigid (PL), triglyceride (TG) and non-esterified fatty acid (NEFA) in serum, and of CHO and TG in the liver, were significantly lower in the gastrectomized rats than in the normal rats when a diet containing 15% safflower oil (SO) was given.
2) The gastrectomized rats fed the diet containing 15% MCT showed increased concentrations of these lipids, especially TG and NEFA, in serum compared with the gastrectomized rats fed SO. Also, in proportion to the increase in MCT to SO ratio, the concentrations of these lipids in the gastrectomized rats were increased.
3) No significant differences in the results of liver function tests were observed among these groups. In the case of non-fasting, the concentration of serum ketone bodies was slightly higher in the gastrectomized rats fed MCT composed with those fed SO. However, after fasting, the concentrations of serum ketone bodies did not show any significant difference in any of the groups, and were remarkably higher than those in non-fasting rats.
These results indicated that MCT improved the lipid metabolism of gastrectomized rats and had no adverse effects on liver funtion and serum ketone bodies in gastrectomized rats.
