Abstract
The effect of the ethanol-utilizing yeast Candida solicola WY-1, which is tolerant to acid and ethanol, on blood ethanol and acetaldehyde concentrations in rats fed ethanol were examined. When the C. solicola cells (3g/kg b. w.) were administered to rats 5min before ethanol (2g/kg b. w.) administration, maximum blood ethanol and acetaldehyde levels were 37% and 23%, respectively, less than those in non-cell-fed rats, causing a larger decrease than in commercial diet-fed rats (3g/kg b. w.). When heat-treated C. solicola cells were tested, no decrease in blood ethanol or acetaldehyde concentration occurred. These results suggest that the decreases in concentration were caused by the ethanolmetabolizing enzymes of C. solicola.
