Ratio of Branched-chain Amino Acids to Aromatic Amino Acids (Fischer's Ratio) in Patients with Multiple Myeloma, Malignant Lymphoma and Chronic Renal Failure

Abstract

The concentrations of free amino acids in plasma of patients with multiple myeloma (MM), malignant lymphoma (ML) and chronic renal failure (CRF) were determined using an automatic amino acid analyzer. Values of plasma ΣNEAA (total non-essential amino acids) in patients with MM, ML and CRF were higher than in normal subjects. Therefore, ΣEAA (total essential amino acids) /ΣNEAA ratios (E/N ratios) in patients with MM, ML and CRF were significantly lower than in normal subjects. The ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) in patients with MM and ML was significantly lower than in normal subjects.