Effects of Dietary myo-Inositol and Phytic Acid on Hepatic Lipids Accumulation in Rats Fed on Sucrose or Orotic Acid

Abstract

Sucrose-fed rats exhibited enhanced hepatic concentrations of total lipids, triglyceride and cholesterol, and enhanced activities of glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) and malic enzyme (ME, EC 1.1.1.40) in comparison with corn starch-fed rats. These increases due to sucrose feeding were significantly depressed by dietary myo-inositol and phytate. On the other hand, orotic acid-fed rats exhibited enhanced hepatic concentrations of total lipids, triglyceride and cholesterol, and reduced hepatic activities of G6PD and ME. These animals also showed low serum concentrations of triglyceride, cholesterol and phospholipid and depressed growth and food efficiency in comparison with the controls. The depressions of growth and food efficiency that had been caused by orotic acid intake were ameliorated by dietary myo-inositol, although dietary phytate had no significant influence. However, neither dietary myo-inositol nor phytate ameliorated the fatty liver caused by orotic acid intake. In the present study, serum concentrations of lipids were not significantly influenced by dietary myo-inositol and phytate. These results suggest that dietary myo-inositol and phytate might both protect against the accumulation of hepatic lipids derived from enhanced hepatic lipogenesis.