Abstract
Changes in the tissue contents of several nutrients with age have been reported in the Senescence Accelerated Mouse (SAM). In this study, the effect of aging on the status of thiamine in tissues of SAM mice was studied. Both males and females of both SAMP1 and SAMR1 fed a commercial diet were used for the study. Thiamine contents were measured in the liver, brain, kidney, heart and skeletal muscle in these mice at the ages of 2, 6 and 10 months. In the kidney, the thiamine content in SAMP1 was lower than that in SAMR1 at each respective age in both males and females. However, in the heart and muscle, the thiamine content in SAMP1 was higher than that in SAMR1 at each respective age in both males and females. The heart thiamine content of male SAMP1 decreased significantly with age. These results suggest that genetic factors are related to the age-associated changes in tissue thiamine levels.
