Abstract
The present study suggested that the mechanism responsible for greater body fat accumulation in rats fed a beef tallow diet compared with rats fed a safflower oil diet was related to the following factors induced by reduction of sympathetic nerve activity in peripheral tissues. 1) Reduction of diet-induced thermogenesis and an increase of the serum insulin level. 2) Decrease of lipolysis in adipose tissue. 3) Decrease of lipid uptake into BAT, heart and skeletal muscle from the blood stream. 4) Increase of lipogenesis in the liver. Moreover, the lower sympathetic activity in rats fed a beef tallow diet may be caused by a decrease of norepinephrine turnover rate and β-adrenergic receptor binding in the hypothalamus.
