Nippon Eiyo Shokuryo Gakkaishi
Online ISSN : 1883-2849
Print ISSN : 0287-3516
ISSN-L : 0287-3516
Antioxidative Activity and Protective Effect of Fermented Plant Extract on Ethanol-induced Damage to Rat Gastric Mucosa
Hideki Okada, Katsuhiro Kudoh, Eri Fukushi, Shuichi Onodera, Jun Kawabata, Norio Shiomi
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Keywords: fermented plant extract, ethanol-induced damage to gastric mucosa, antioxidative activity, caffeic acid, chlorogenic acid
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2005 Volume 58 Issue 4 Pages 209-215

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Abstract

A fermented plant extract (FPE) was prepared from about fifty kinds of vegetables and fruits, and its protective effect against ethanol-induced damage to rat gastric mucosa was investigated. Oral administration of FPE (200mg/kg) significantly reduced the damage to the rat gastric mucosa induced by ethanol. Antioxidative compounds were isolated from FPE by extraction with ethyl acetate, chromatography on an Amberlite XAD-2 column, and HPLC with a ODS column. The compounds were identified as chlorogenic acid and caffeic acid by LC-MS, TOF-MS, and NMR analyses. Chlorogenic acid and caffeic acid (100-200mg/kg bw) were confirmed to effectively protect against gastric mucosal damage induced by ethanol in rats.

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