2026 年 43 巻 3 号 p. 245-249
In recent years, the effectiveness of multidomain interventions for dementia prevention has been reported in many countries. In Japan, the J–MINT study was launched in 2019 to examine whether a multidomain intervention program tailored to the Japanese lifestyle could prevent cognitive decline. In this trial, the efficacy of a multidomain intervention was evaluated in individuals with mild cognitive impairment (MCI). Although no significant improvement was observed in the primary outcome of overall cognitive function, participants who attended ≥70% of the exercise sessions showed significant cognitive improvement. In addition to cognitive outcomes, improvements were observed in nutritional status, physical function, social participation, and reductions in blood pressure. Responder analyses further revealed that the intervention produced beneficial effects, particularly in APOE ε4 carriers, individuals with elevated baseline glial fibrillary acidic protein levels, and those with lifestyle–related diseases. Moreover, an economic evaluation of the J–MINT study demonstrated that, compared with usual care, J–MINT was both cost–saving and more effective. Research is currently underway to implement the evidence generated by the J–MINT study into real–world practice.
