Primary malignant lymphoma of the salivary glands is a relatively rare disease, accounting for 4.7％ of all malignant lymphomas. Herein, we report a case of a 71-year-old female patient with primary malignant lymphoma in the submandibular gland. Several months ago, the patient visited the hospital, presenting with swelling of the right lower jaw. Computed tomography revealed a well-defined mass in the right submandibular gland, and magnetic resonance imaging showed a low signal on T1-weighted imaging and a slightly high signal on T2-weighted imaging. 67Ga scintigraphy also revealed localized accumulation in the right submandibular gland. Ultrasonography showed an internal mixture of anechoic and hypoechoic contents, with confirmation for linear high-intensity echo, and Doppler ultrasonography revealed abundant blood flow and enhanced posterior echo. Moreover, blood tests showed normal values for EBV-IgG antibody （＋）, LDH, and soluble IL-2 receptors. Based on these results, a diagnosis of right submandibular gland tumor was made, and the patient underwent excision of the right submandibular gland tumor under general anesthesia. Histopathological examination revealed MALT lymphoma, and she was subsequently referred to the hematology department. Currently, no recurrence or metastasis has been observed, and the patient has been making good progress. Given the findings of this report, it should be noted that malignant lymphoma originating in the salivary glands has few clinical symptoms, and imaging may mimic well-defined benign neoplastic lesions in a capsule, which often makes preoperative diagnosis difficult.
