各種骨補填材とe-PTFE膜を用いた骨欠損組織再生後の顎骨におけるチタンインプラントの骨結合についての比較研究

抄録

The purpose of this study was to morphologically and histomorphometrically evaluate the osseointegration between regenerated bone and dental implants. Following a four-month healing period after tooth extraction of beagle mandible, e-PTFE membranes were placed over the standardized defects. Subsequently, five different bone-filling materials were randomly placed under the membranes. The materials used were autogenous bone graft, demineralized freeze-dried bone powder of dog origin, bovine inorganic xenograft, beta-tricalcium phosphate, collagen-fleece, and membrane alone as a control. Following a healing period of six months, non-submerged implants with a titanium plasma coated surface were inserted in the sites. Three months after implant placement, the specimens were histologically analyzed in the non-decalcified sections.
On the radiographic measurement of defect sites in the beagle's mandibles at the ridge augmentation, recovery of bone height by GBR in DFDBA, auto-bone and TCP graft sites was much better than in the control, collagen and Bio-Oss^® graft sites with statistically significant differences.
No statistically significant differences were revealed in direct bone contact rate between the six groups. The percentages of Bio-Oss^® remnants demonstrated higher rates than the other four materials three months after implantation. The results suggested that implants could achieve good bone contact with regenerated bone in defects filled with a variety of bone filling materials.