水酸化カルシウムペースト剤の骨形成に及ぼす影響に関する病理組織学的研究

抄録

The purpose of this study was to evaluate how the application of OSTEOINDUCTAL^® after tooth extraction affects alveolar bone formation. OSTEOINDUCTAL^® is a calcium hydroxide pharmaceutical. Twenty-one Wistar rats were divided into two groups. In both groups, teeth were extracted. The control group underwent no further treatment. OSTEOINDUCTAL^® was applied after tooth extraction in the experimental group. The experimental animals were sacrificed for specimen preparation at 4 weeks and 8 weeks. After paraffin embedding, tissues were sliced at 5 μm thickness and stained with H-E. From each specimen, the proportions of the bone dimensions were calculated using a Micro Scope System (MS-803, MORITEX, Tokyo, Japan). In the control group, the bone formation was slight at 4 postoperative weeks, and a pit formed by the invasion of the gingival connective tissue after extraction of the tooth lacuna was clearly present. In the experimental group, considerable new bone was formed. The experimental group had significantly more the bone formation at 4 weeks. However, at 8 weeks, the difference between the control and the experimental groups was only slight.
The results of this study suggest that OSTEOINDUCTAL^® may speed up postoperative bone induction.