抄録
β-TCP can stimulate bone formation;however, its molecular mechanism is unclear. In this study, an implant drill was used to make bone defects in Beagle dog mandible, and β-TCP was filled into the bone defects. After isolation of mRNA, gene expression levels were monitored by dog DNA microarray. The gene expression of decorin was enhanced by β-TCP, and decorin gene expression was increased through TGF-β by β-TCP. An immunohistochemical study demonstrated that the decorin protein was also increased by β-TCP, since decorin binds with TGF-β and plays a role in osteoblast maturation. Taken together, the stimulation of decorin expression by β-TCP might be a part of the mechanism in accelerating bone formation.
