抄録
The bone formation in the soft tissue with combined grafts of three categories of HAP granules and autogeneous bone marrow were examined histologically.
Two kinds of HAP granules were on the market (Apaceram® and Bonetite®) and another was newly developed (Kobeceram). Autogeneous bone marrow was obtained from New Zealand white rabbit tibia. Combined materials of each HAP granule and bone marrow were grafted into the abdominal subcutaneous regions of rabbits, and bone formation at four weeks after graft were observed histologically.
The results were as follows: In all groups, new bone formations, which were induced with osteoprogenitor factor in bone marrow, were observed, and histological examination of the 4-week specimens revealed excellent HAP-bone complex formations in the Apaceram® and Kobeceram groups. Process of HAP-bone complex formation with combined graft of HAP granules and autogeneous bone marrow was similar to that which was observed when HAP granules were grafted into the rabbit tibia.
