歯性感染症における分離菌の薬剤感受性と抗菌薬使用密度

抄録

We investigated the antimicrobial susceptibility of Prevotella intermedia and the Streptococcus anginosus group isolated in Nippon Dental University Niigata Hospital from 2002 to 2011. P. intermedia were isolated from 9 strains in 78 closed abscesses and 91 strains in 431 open abscesses of odontogenic infections. The S. anginosus group was isolated from 39 strains and 122 strains, respectively. MIC₅₀ of ampicillin (ABPC) against P. intermedia were > 8μg/mL in closed abscesses and > 1μg/mL in open abscesses. MIC₉₀ of clindamycin (CLDM) were ≤ 0.12μg/mL in closed abscesses and > 4μg/mL in open abscesses. Benzylpenicillin (PCG) showed good antimicrobial activity against the S. anginosus group. Susceptibility rates of CLDM against the S. anginosus group were about 90%. Antimicrobial use density (AUD) of penicillins decreased from 2002-2006 to 2007-2011. Susceptibility rates of ABPC against P. intermedia were 36% on inpatients. Susceptibility rates of CLDM were 100% in 2002-2006 and 72.7% in 2007-2011 on inpatients. Susceptibility rates of PCG and CLDM against the S. anginosus group were stationary on inpatients.
We need to keep observing antimicrobial susceptibility of P. intermedia and the S. anginosus group.