エスモロールまたはニカルジピンで血圧コントロールしたSHR/Izmの舌にアドレナリンを投与した場合の循環動態の比較

抄録

This study was investigated that in order to interaction of cardiovascular effects for adrenaline and hypotension agents, cardiac function was measured for adrenaline administered to blood pressure controlled SHR/Izm by nicardipine or esmolol. Under 5mg/kg/h propofol infusion, arterial blood pressure catheter and P-V catheter were inserted to SHR/Izm. Four hundred micro g/kg/min esmolol or 1 micro g/kg/min nicardipine were infused and 20 micro g/kg adrenaline injected to tongue. Then there were measured blood pressure, pulse rate, stroke volume continuously. Systolic and diastolic pressure elevated from 5 min to 20 min on esmolol. There were significant differences between esmolol and nicardipine at 20 min of systolic, 20min and 30min of diastolic pressure. Pulse rate increased from 5 min to 30 min on nicardipine, there were significant differences between nicardipine and esmolol at 20 min. Stroke volume increased at 10 min, 20 min, 30 min on nicardipine、there were significant differences between esmolol and nicardipine at 5 min, 10 min, 20 min, 30 min. Blood pressure elevated when adrenaline injected to tongue of esmolol administered SHR/Izm, pulse rate and stroke volume increased when adrenaline and nicardipine administered.