シトラール，シンナムアルデヒド，オリゴノール^®，カプリン酸を含有する飴の口腔カンジダ症に対する効果

抄録

Purpose：The purpose of this study was to investigate the efficacy of a candy containing citral, cinnamaldehyde, oligonol, and capric acid for oral candidiasis.

Methods：The effectiveness of the candy was evaluated in a double-blind placebo-controlled trial in 20 patients with hyposalivation and erythematous candidiasis. A definitive diagnosis of oral candidiasis was made on the basis of clinical features of the lesion, microscopic detection of filamentous fungal elements in smear specimens, and fungal culture. Twenty subjects were divided into two groups, test candy group and placebo group, and administered the test or placebo candies twice a day for 7days. Lesions were clinically evaluated. Candida albicans （viable CFU/ml） in oral rinse samples were measured on days 0 and 8.

Results：Atrophy of the dorsum of the tongue （p＝0.015）, redness of the dorsum of the tongue （p＝0.046）, and redness of the oral mucosa （p＝0.015） were significantly improved in the test-candy group （Wilcoxon t-test）. No statistically significant differences were observed in viable C. albicans CFU/ml and moisture content in the oral mucosa between test-candy group and placebo group.

Conclusion：The test-candy significantly improved signs of erythematous candidiasis, suggesting that the test candy can be useful in prevention of oral candidiasis in patients with hyposalivation.