歯科薬物療法
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
総説
dectin-1受容体の認識を介したβ-glucanによる破骨細胞分化の制御と薬物療法の可能性
有吉 渉
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ジャーナル 認証あり

2022 年 41 巻 1 号 p. 11-18

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抄録

Coordinated co-stimulatory signals mediated by several immunoreceptors are important for the regulation of osteoclast differentiation. Dectin-1 is one of the pattern recognition receptors of β-glucan and is expressed on the surface of hematopoietic osteoclast precursor cells. In this review, we discuss the biological effects of β-glucans on bone-resorbing osteoclasts. Several β-glucans negatively regulate osteoclast differentiation by binding to dectin-1. Furthermore, we demonstrated the possibility of β-glucan as a candidate of osteoclast-targeting gene delivery system. Future studies concerning the relationship between the β-glucan structure and its biological effects on osteoclast are required for the development of novel pharmacological treatment for bone-related diseases.

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© 2022 日本歯科薬物療法学会
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