Abstract
In seven healthy volunteers, blood and saliva concentration of physiological granulocyte colony-stimulating factor (G-CSF) were measured in order to examine the local effects on the intraoral cavity. Furthermore, the pharmacokinetics of a G-CSF agent (lenograstim) was studied.
The results were as follows :
1) The blood concentration of physiological G-CSF was 9.5±1.8pg/ml (n=7), and the saliva concentration was 21.2±11.9pg/ml (n=7) . That is to say, the saliva concentration of physiological G-CSF had about a two-fold increase as compared with the blood concentration. This suggests that G-CSF in saliva directly augments the function of salivary polymorphonuclear leukocytes (S-PMN) .
2) Transmigration of G-CSF agent into saliva is less than 10% of that into blood.
