慢性歯性上顎洞炎の薬物療法

―14員環マクロライド系抗生物質ロキシスロマイシンの長期投与療法―

抄録

Odontogenic chronic sinusitis was treated by long-term administration of roxithromycin, which is a 14-membered-ring macrolide antibiotic, pronase and carbocistein, and a good result was obtained. The subjects were 26 patients with odontogenic chronic sinusitis who visited our Department from January 1994 to October 1995. They were 16 males and 10 females, and their mean age was 42.6 years. The drugs were administered orally in a dose of 150 mg twice a day for roxithromycin, 18, 000 tyrosine units/day for pronase, and 500 mg three times a day for carbocistein. The mean administration period was 132.2 days. The efficacy of the regimen was assessed based on clinical symptoms and MRI findings. The efficacy rating was “improved” or better in 95.0% of the patients in terms of clinical symptoms, while the same rating was 53.3% in terms of MRI findings. In both assessments, there were no“worsened”cases, and no adverse reactions were noted. In conclusion, the results of this study suggested that the regimen is effective for treatment of odontogenic chronic sinusitis.