ヒト歯周組織由来細胞の化学走化性に対するテトラサイクリン系抗生物質の影響
1997 年 16 巻 1 号 p. 1-5
詳細
1997 年 16 巻 1 号 p. 1-5
It has been shown that the human periodontal ligament fibroblast conditioned medium (HPLF-CM) enhanced chemotaxis and attachment of HPLF and human gingival fibroblast (HGF) . The present investigation was conducted to evaluate the effect of tetracyclnes on chemotaxis of HPLF and HGF. Twenty μg/ml doxycycline (DOXY) and 20μg/ml minocycline (MINO) enhanced chemotactic activity of both cells. Twentyμg/ml tetracycline (TC) significantly (p<0.05) increased chemotactic activity of HGF compared with MCDB 107, but did not influence chemotaxis of HPLF. The data suggested that DOXY and MINO may contribute to the development of periodontal regeneration.
