Recently, the number of infectious diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) has increased. In the oral and maxillofacial region, MRSA have often been detected in samples of malignant tumor patients. There are few antibiotics for MRSA, but vancomycin (VCM) is known to be useful for MRSA infection.
Eleven patients with MRSA infection in the oral and maxillofacial region were treated and the clinical efficacy and side effects of VCM administration were investigated. While monitoring the concentration of VCM in peripheral blood, VCM alone or VCM with another antibiotic, fosfomycin (FOM) or flomoxef (FMOX) were administered. Furthermore, the background of each patient with MRSA infection in this region was discussed. The results were as follows:
1. The combination chemotherapy of VCM and another antibiotic was very useful for improving clinical symptoms in MRSA infection.
2. The administration of VCM with FMOX was more effective for MRSA infection than that of VCM alone or VCM with FOM.
3. The side effects of VCM were effectively prevented by monitoring the VCM concentration in peripheral blood.
