Abstract
Minocycline has been frequently inserted topically into the periodontal pocket of periodontal disease. The causative organisms of periodontal disease were collected from clinical cases. Twenty strains of Prevotella intermedia, 20 strains of Porphyromonas gingivalis, 20 strains of Capnocytophaga sp., 20 strains of Fusobacterium nucleatum, 15 strains of Eikenella corrodens, and 15 strains of Actinobacillus actinomycetemcomitans were identified and stocked. MICs of minocycline were measured for those organisms. MIC ranges and MIC90 were as follows : Prevotella intermedia (≤0.025-3.13, 1.56), Porphyromonas gingivalis (≤0.025-1.56, 0.39), Capnocytophaga sp. (0.05-0.2, 0.10), Fusobacterium nucleatum (≤0.025-3.13, 0.10), Eikenella corrodens (0.2-1.56, 0.78), and Actinobacillus actinomycetemcomitans (0.39-0.78, 0.78) .
To evaluate therapeutic agents for periodontal disease, one should measure the susceptibility of causative organisms and the effusion level in periodontal pockets.
Minocycline maintained favorable susceptibility to organisms of periodontal disease.
