抄録
In order to investigate how the immunological supression is related to the outbreak of oral and maxillofacial infections, using the experimental buccal abscess induced by carageenin in leukocytopenic rats, the pathological changes were examined after inoculation of S. pyogenes S-8 into the cavity of the abscess.
1. The number of white blood cells decreased by 1/8 to 1/12 after administration of cyclophosphamide (CPA), however, no rats died under this condition.
2. After inoculation of S. pyogenes, the diameter of the abscess and the wet weight of exudate in leukocytopenic rats were smaller in comparison with normal rats at most masurement points.
3. Histopathologically, inflammatory cell infiltration in normal rats was much more predominant than in leukocytopenic rats, however, the extent of infiltration in leukocytopenic rats was longer than in normal rats.
4. The number of viable cells of S. pyogenes in leukocytopenic rats was almost the same as in normal rats until 36 hours after inoculation, however, viable cell counts in normal rats tended to decrease in 48 hours.
5. From the results above, the number of viable cells of S. pyogenes in the abscess was not extremely increased even in leukocytopenic rats, so oral and maxillofacial region was thought to be very resistant to infection and the outbreak of infection did not necessarily occur in such a leukocytopenic condition.
