A double-blind clinical evaluation of Suprofen after tooth extraction comparing with indomethacin

Abstract

A multi-clinic double-blind study was conducted to examine the analgesic efficacy and safety of Suprofen, a new non-steroidal anti-inflammatory agent, in comparison with indomethacin after tooth extraction. Patients were administered either Suprofen 200mg or indomethacin 25mg.
1. Statistically analyzed cases were 101 with Suprofen group and 106 with indomethacin group, 207 as total. Drop out and excluded cases were 5 with Suprofen group and 7 with indomethacin group.
2. In global improvement rating of a pain and overall clinical evaluation, Suprofen group was significantly superior to indomethacin group (ρ<0.01) .
3. In time till appearance of effect, Suprofen group was significantly faster to indomethacin group (ρ<0.01) .
4. Side effects were reported 7 cases in Suprofen group and 5 cases in indomethacin group, and no significantly differences were shown between the two groups.
Summarizing the above results, it can be concluded that Suprofen is a useful drug after tooth extraction and that analgesic efficiency and safety on Suprofen administration were better than indomethacin administration.