A double-blind study of Suprofen (TO-177) in the treatment of post-operative oral surgery pain

HIROSHI TAKAI; KATSUYOSHI IKESHIMA; HIKARU OHMURA; KEN-ICHI MICHI; KEN-ICHI SAITO; KOHSUKE OHNO; SABURO SEKIYAMA; KATSUHIKO YUKI; ATSUYOSHI SEGAWA; KAZUO SAKAIZUMI; TETSUO NAGAI; MASAMI FUJINO; GEN-IKU KOHAMA; SHIN-YA DENSYO; JUNJI KYOGOKU; HIROYASU NOMA; TAKASHI KAKIZAWA; GENYUKI YAMANE; MASAYASU SUGIHARA

doi:10.11263/jsotp1982.2.51

HIROSHI TAKAI, KATSUYOSHI IKESHIMA, HIKARU OHMURA, KEN-ICHI MICHI, KEN-ICHI SAITO, KOHSUKE OHNO, SABURO SEKIYAMA, KATSUHIKO YUKI, ATSUYOSHI SEGAWA, KAZUO SAKAIZUMI, TETSUO NAGAI, MASAMI FUJINO, GEN-IKU KOHAMA, SHIN-YA DENSYO, JUNJI KYOGOKU, HIROYASU NOMA, TAKASHI KAKIZAWA, GENYUKI YAMANE, MASAYASU SUGIHARA

Author information

HIROSHI TAKAI
First Department of Oro-Maxillo-Facial Surgery, Tohoku Dental University
KATSUYOSHI IKESHIMA
First Department of Oro-Maxillo-Facial Surgery, Tohoku Dental University
HIKARU OHMURA
First Department of Oro-Maxillo-Facial Surgery, Tohoku Dental University
KEN-ICHI MICHI
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
KEN-ICHI SAITO
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
KOHSUKE OHNO
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University
SABURO SEKIYAMA
Second Department of Oral Surgery, School of Dentistry, Iwate Medical University
KATSUHIKO YUKI
Second Department of Oral Surgery, School of Dentistry, Iwate Medical University
ATSUYOSHI SEGAWA
Second Department of Oral Surgery, School of Dentistry, Iwate Medical University
KAZUO SAKAIZUMI
Dentistry & Oral Surgery, School of Medicine, Keio University
TETSUO NAGAI
Dentistry & Oral Surgery, School of Medicine, Keio University
MASAMI FUJINO
Dentistry & Oral Surgery, School of Medicine, Keio University
GEN-IKU KOHAMA
Oral Surgery, Sapporo Medical College
SHIN-YA DENSYO
Oral Surgery, Sapporo Medical College
JUNJI KYOGOKU
Oral Surgery, Sapporo Medical College
HIROYASU NOMA
First Department of Oral Surgery, Tokyo Dental College
TAKASHI KAKIZAWA
First Department of Oral Surgery, Tokyo Dental College
GENYUKI YAMANE
First Department of Oral Surgery, Tokyo Dental College
MASAYASU SUGIHARA
Hospital Pharmacy, Tokyo Women's Medical College

Keywords: Suprofen, Asprin, Tooth extraction of mandibular impacted tooth, Double-blind study, Non-steroidal antiinflammatory analgesic agent

JOURNAL FREE ACCESS

1983 Volume 2 Issue 1 Pages 51-62

DOI https://doi.org/10.11263/jsotp1982.2.51

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Abstract

A multi-center double-blind study in comparison with aspirin was conducted to evaluate the effectiveness, safety and usefulness of Suprofen (TO-177), a new non-steroidal analgesic/anti inflammatory agent, in tooth extraction of mandibular impacted wisdom tooth.
Patients were treated with Suprofen (SP) 100mg three times a day or aspirin (AP) 500mg three times a day.
The results were obtained as follows.
1) Total treated cases were 272 (SP: 133 cases, AP: 139 cases) . 4 cases were excluded.
2) According to the clinical efficacy, the ratio of“good or better”was 74.4% with SP group and 61.2% with AP group. There was a significant difference between two groups (p<0.001) .
3) Side effects were reported 3 cases (2.3%) SP group and 10 cases (5.1%) AP group.
4) In the general utility rating, the ratio of“useful or better”was 72.7% with SP group and 56.7% with AP group. There was a significant difference between two groups (p<0.001) .
The results indicate that Suprofen is a safe and useful anti inflammatory analgesic agent.

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