Abstract
Cefuroxime (CXM) concentrations in human serum, gingiva, mandibular bone, and dental follicle following a single oral administration of cefuroxime axetil (CXM-AX) (500mg) were studied. The mean concentrations in serum, gingiva, mandibular bone, and dental follicles peaked at identical times, 2 hours after administration, and were 5.60μg/mL, 2.02, 0.81, and 1.70μg/g, respectively. The mean concentration ratios of gingiva/serum, mandibular bone/serum, and dental follicles/serum at the peak time were 0.39, 0.16, and 0.34, respectively. Most of the CXM concentrations in gingiva, mandibular bone, and dental follicles exceeded the MIC for 90% of clinically isolated strains of oral streptococci. Thus, CXM-AX may be a valuable antimicrobial agent for the treatment of odontogenic infection.
