Fundamental and clinical studies on acetyl Midecamycin (MOM) tablets in the field of oral surgery

Abstract

Fundamental and clinical studies on MOM were conducted in the field of oral surgery, and the following results were obtained.
1) The antibacterial activity of MOM was similar to josamycin against gram-positive bacteria.
2) Maximum concentrations of MOM after administration of 400 mg in fasting healthy volunteers were 8.61 μg/ml in serum at 30 min, and 3.18 μg/ml in saliva at 30 min.
3) MOM was administered to 7 patients with oral surgery infections, and the therapeutic efficacy was rated as excellent in 2 patients, good in 4, poor in 1, with the overall effectiveness rate being 86%. No side effects were observed in any cases.
From the above results, it is feasible that MOM may be positively used for the treatment of oral surgery infections or for the prevention of postoperative infections in the field of oral surgery.