Clinical effects of Cefmenoxime (SCE-1365) in oral cancer patients after surgery

Abstract

A clinical study of Cefmenoxime (SCE-1365), used for postoperative chemoprophylaxis, was conducted in 12 patients with oral cancer. Surgery consisted of mainly radical resection, radical neck dissection and simultaneous reconstruction; trachostomy and blood transfusion were also performed in 5 patients each. In contrast to the use of antibiotics in treating nonspecific infections, difficulty existed for evaluating the clinical efficacy of Cefmenoxime; however, our results confirmed its clinical usefulness in 9 patients and its safety in all 12 patients.