抄録
We carried out a basic study on T3262. One hundred and fifty milligram of T3262 were administered to 8 healthy volunteers, and blood level and saliva penetration were investigated under 2 conditions, fasting and non fasting.
A pharmacokinetic study was performed using a one compartment model. The parameters calculated were as follows :
Blood Saliva
Fasting Non fasting Fasting Non fasting
Tmax (h) 1.51 1.35 1.88 1.76
Cmax (μg/ml) 0.61 0.66 0.37 0.49
T1/2 (h) 3.11 3.86 4.08 4.48
AUC (μg⋅ml/h) 3.65 4.54 2.88 4.01
