抄録
Fundamental and clinical studies were carried out on CMNX, a new cephamycin antibiotics. The results were as follows:
1) The concentration of this antibiotics in serum, gingiva and jaw bone tissues was measured after an intravenous one shot injection of 1 g of CMNX on a patient. The mean serum, gingiva, and jaw bone tissue concentration were 47.7 μg/ml, 18.5 μg/g, 7.3 μg/g at 1 h, respectively.
2) In vivo antibacterial activity of CMNX was studied on 50 clinical isolates to CMNX. CMNX had a wide spectrum of antibacterial activity against gram-positive and gram-negative bacteria. The MIC80 against aerobes was 12.5 μg/ml, and against anaerobes was 6.3 μg/ml.
3) The clinical efficacy of CMNX was 95% based on committee judgement and 86% based on doctors' judgement.
4) From the above results, it was concluded that CMNX was a useful new antibiotic in the field of oral surgery.
