Factors influencing on the onset of food allergy -Invention of the enzyme digested food with the induction of oral tolerance (2005 Gifu)-

Abstract

The onset of food allergy is modified by the genetic and environmental factors. It is known that breast milk influences the onset of food allergy. We investigated the cytokine level in breast milk. It was shown that the level of IFN-gamma and TGF-beta 1, 2 in breast milk at 1 week after delivery were different from breast milk at 1 month after delivery. The change of cytokine level in breast milk might modify the onset of oral tolerance induction.
Beta-lactoglobulin (BLG) is one the major allergen in cow's milk. We developed the BLG which has have T cell epitope but does not have B cell epitope using enzyme digestion. This BLG showed the oral tolerance induction in some patients with cow's milk allergy. Furthermore, we try to develop the effective and safe method of oral tolerance induction in food allergy.