Abstract
Non-immunoglobulin (Ig) E (IgE)-mediated gastrointestinal (GI) allergies are classified according to clinical manifestations such as food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy (FPE). However, in infants, since GI allergies may not necessarily fall under these categories, the term “GI allergy in infants” is used to refer to GI allergies in infants in Japan. Although GI allergy in infants is classified on the basis of symptoms, few attempts have been made toward grading it on the basis of severity and demonstrating its relevance. Hence, we propose a severity grading system for GI allergy in infants and compare the clinical features, such as blood test results, endoscopic findings, treatments, and prognoses, between three severity grading. Our results indicate that the most severe grading represents distinct pathophysiology of GI allergy in infants.
