Abstract
The cariogenicity of Panorich and Panorich S was examined in in vitro and in vivo experiments. Mutans streptococci femented Panorich and Panorich S. Panorich and Panorich S inhibited both glucan synthesis by glucosyltransferases of mutans streptococci from sucrose and sucrose-dependent adherence of these organisms to glass surfaces. In rats infected with mutans streptococci, Panorich and Panorich S showed significantly lowered caries-inducing and plaque forming activity, when compared to sucrose. Moreover, Panorich and Panorich S significantly inhibited sucrose-induced dental caries in rats infected with S. sobrinus 6715. These results indicate that Panorich and Panorich S could serve as anti-cariogenic sweeteners.
