Abstract
High-entropy alloys (HEAs) have attracted attention as a new material with excellent features such as solid solution hardening due to the high entropy effect derived from more than five constituent elements. In this review article, the alloying design of HEAs for biomedical applications (BioHEAs), which was firstly developed in Japan, is introduced. By super rapid cooling using the metal additive manufacturing with the laser beam as a heat source, the elemental segregation often seen in HEAs was suppressed, and true HEAs were developed to achieve high functionality.