2018 Volume 23 Issue 2 Pages 96-101
We examined the prognosis of 90 newborn infants delivered by mothers with psychiatric disorders (excluding epilepsy) at the Obstetrics and Gynecology Department of Shiga University of Medical Science from January 2010 to May 2015. We investigated factors related to NICU admission, onset of neonatal withdrawal syndrome (NWS), and admission to an orphanage. We performed Mann-Whitney U test, Fisher’s exact test for statistical processing. NICU admission was associated with use of tricyclic/tetracyclic antidepressants (P=0.0094), use of anxiolytics (P=0.0157), and the number of concomitant drugs (P<0.0001). NWS was related to maternal age (P=0.0423), use of SSRI (P=0.0023), use of tricyclic/tetracyclic antidepressants (P=0.0372), and the number of concomitant drugs (P=0.0003). The factor related to orphanage admission was self-discontinuation of medication (P=0.0204). In multiple logistic analysis, NICU admission was most closely associated with the number of concomitant drugs (odds ratio 5.862, 95% CI ; 1.784-19.259) and orphanage admission was associated with self-discontinuation of medication (odds ratio 13.12, 95% CI ; 1.078-159.609). In patients with these risks, psychiatric disorders should be adequately controlled before pregnancy, patients should be instructed not to discontinue medication, and relevant healthcare workers (e.g., NICU staff and social workers) should coordinate after delivery.
