Abstract
The patient was a 33 years old woman who suffering from severe pre-menstrual syndrome (PMS). On the menstruation, follicular phase, ovulation and luteal phase, BBT, serum level of Eu progesterone and indices of HPA-axisactivities (ACTH and cortisol) were measured during an one menstruational cycle. Also, three kinds of psychological assessments were tested and the changes of P300 waves on EEC were investigated. The ratio of progesterone and E1 showed significant lower score in the luteal phase. The patients' POMS score of anger and haste was the highest in the luteal phase and this was explained by the differences between expected value of progesterone-E_1 ratio and the real ratio. Also the depressive score, which was significantly higher in the luteal phase, was explained by ACTH. We suggested depressive state in the luteal phase was due to hyper activation of HPA-axis and the emotional declination to anger and haste in the same phase owes to the lower level of progesterone. Treatment using SSRI was thought to be effective in patinets with PMS.
