Abstract
Crosslinked N-Telopeptides of Type 1 Collagen (NTx) is produced by the osteoclasts on bone tissue and is widely recognised as a specific and sensitive marker for bone resorption. We found the ratio of NTx and B-ALP increase as the ultrasound bone densities decrease in 28 young Japanese healthy women. And NTx/B-ALP ratio was significantly explained by the degree of IL-6 by using stepwise-regression. The subjects who showed higher IL-6 than the averages, declined to be aggressive and hateful in personality assessment. We suggested emotional stresses affect not only bone strength but also activities of peripheral inflammatory cytokine. The importances of Psycho-Neuro-Immuno-logical view-points in womens' psychosomatic diseases were emphasised.
