抄録
To evolve biology from the trial-and-error approach into a deterministic and predictive science, an engineering approach is both helpful and necessary. The Computer Aided Design (CAD) approach comprises of process analysis (systems biology) and systems engineering (synthetic biology). The key challenge in synthetic biology is to make complex biological systems that are programmable, predictable and stable. In my talk I will begin by describing classic engineering driven design and manufacture approach. I will then move on to computational systems biology approach and explain key concepts there. I intend to spend most of my time on synthetic biology and link all three sciences that, in future, would help us design pathways, networks and by extension, organisms with precision. I will present examples to argue that CAD biology is rational approach. It is indispensable, intuitive and makes use of standard biochemical and physical principles.
