2022 年 10 巻 4 号 p. 108-116
Aim: To clarify the relationship between the incidence of gestational diabetes mellitus (GDM) with or without hypertensive disorders of pregnancy (HDP) and the incidence of small-for-gestational-age (SGA) infants.
Methods: We conducted a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation in 455 pregnant women who were classified into four groups according to their GDM and HDP status retrospectively.
Results: The number of SGA infants born to women with GDM+HDP was similar to that born to women with HDP alone. In the GDM group, the SGA rate in women with GDM+HDP was similar to that in women with GDM alone. However, in the non-GDM group, significantly more SGA infants were born to women with HDP alone than to women with no pathology. The mean birthweight SD in women with GDM+HDP was comparable to that in women with GDM alone. However, the birthweight SD in women with HDP alone was significantly lower than that in women with no pathology. By multivariate analysis, birthweight SD<−0.564 was a predictor of HDP in the non-GDM group, but not in the GDM group.
Conclusions: This study showed that GDM might offset the number of SGA infants induced by HDP.
