Management of severe hypertension by nicardipine intravenous infusion in pregnancy induced hypertension after cesarean section

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Aim: The aim was to retrospectively investigate whether intravenous administration of nicardipine might be useful for managing blood pressure (BP) after cesarean section in women with severe pregnancy induced hypertension (PIH).
Methods: Fifty-one postpartum women after cesarean section with severe hypertension (systolic BP [SBP] ≥160 mmHg) (28 preeclampsia [PE] and 23 gestational hypertension [GH]) were enrolled. According to the modified nicardipine sliding scale procedure, a continuous intravenous infusion of nicardipine at 1 to 6 mg/h was given to goal (SBP 120–140 mmHg) by evaluation every 30 min.
Results: Initial SBPs were 172±10 mmHg in PE and 175±11 mmHg in GH. The stable dose of nicardipine was 1.9±0.8 mg/h in PE and 1.4±0.6 mg/h in GH. The stable dose was greater in PE than in GH. Stable SBPs were 133±11 mmHg in PE and 136±11 mmHg in GH. SBP decrease rates were 23±6% in PE and 23±6% in GH.
Conclusion: In this retrospective study, intravenous administration of nicardipine using a sliding scale appeared useful for decreasing BP in both PE and GH.