人工細胞膜上におけるアミロイド形成

抄録

Alzheimer's disease (AD) is induced by the formation of fibrils of amyloidβprotein (Aβ). It is likely that the kinetics of fibril formation of Aβ and their morphology affected the cytotoxicity, because the senile plaque formed by Aβ fibrils is a hallmark of AD. Recently, it has been reported that the interface, such as a solid surface and a lipid membrane interface gave an impact on the fibril formation behavior of Aβ fibrils and their morphology. In this article, a dynamic property of interface to model the biomembrane in the previous reports was introduced. How the artificial biomembranes could affect the fibril formation of Aβ and its morphology was thereafter introduced. These findings would give the better understanding of both the formation mechanism of amyloid fibrils on biomembranes and the pathological mechanism of AD.