産婦人科からみた子宮移植の意義

抄録

Since 2014, more countries have been doing uterine transplants after the world’s first report of a uterine transplant delivery by Professor Brännström’s team in Sweden. Even in Japan, although it has not been applied to humans, transplantation technology has reached a certain level and has reached the stage of preparing for clinical application.

The target of uterine transplantation is a patient with a uterine defect disease who desires fertility treatment, and congenital uterine defect (Mayer-Rokitansky-Küster-Hauser syndrome) can be considered as a consensus. In actual practice, it is important to consider the following points.

1. There are still unresolved issues to be considered and a clinical trial study should be conducted.

2. The choice of donor should be careful. This is because it is necessary to perform highly invasive surgery on a healthy donor in order to perform this technique. Brain death transplantation is also possible, but the hurdles are high in Japan. Therefore, living body transplantation is the main focus.

3. As for the conditions of the recipient, it is necessary to consider that the patient can obtain a pregnant egg, that she is of an age that allows pregnancy and delivery, and that she and her partner desire fertility treatment.

4. In addition, it is necessary to consider the level of medical facilities and what to do about the necessary expenses.

While solving these problems, it is necessary to carry out cross- medical society efforts and proceed with preparations.